Making Tactile Textures with Predefined Affective Properties

A process for the design and manufacture of 3D tactile textures with predefined affective properties was developed. Twenty four tactile textures were manufactured. Texture measures from the domain of machine vision were used to characterize the digital representations of the tactile textures. To obtain affective ratings, the textures were touched, unseen, by 107 participants who scored them against natural, warm, elegant, rough, simple, and like, on a semantic differential scale. The texture measures were correlated with the participants' affective ratings using a novel feature subset evaluation method and a partial least squares genetic algorithm. Six measures were identified that are significantly correlated with human responses and are unlikely to have occurred by chance. Regression equations were used to select 48 new tactile textures that had been synthesized using mixing algorithms and which were likely to score highly against the six adjectives when touched by participants. The new textures were manufactured and rated by participants. It was found that the regression equations gave excellent predictive ability. The principal contribution of the work is the demonstration of a process, using machine vision methods and rapid prototyping, which can be used to make new tactile textures with predefined affective properties

Hydrogel matrix entrapping PLGA-paclitaxel microspheres: Drug delivery with near zero-order release and implantability advantages for malignant brain tumour chemotherapy

10.1007/s11095-009-9922-2Pharmaceutical Research2692101-2114PHRE

Porous polyurethane film fabricated via the breath figure approach for sustained drug release

Bozdoğan, Betül (Aksaray Author)The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55-80% relative humidity. The porous PU films were prepared within various pore structures and sizes, which were adjustable, depending on the fabrication conditions. The humidity and exposure time were examined as variable parameters affecting the surface morphology, wettability, and cytotoxicity. Atorvastatin calcium, a hyperlipidemic agent, was loaded into the porous films during the casting process, and the drug-loading and drug-releasing behaviors of the porous PU membranes were evaluated. Approximately 60-80% of the drug was released in 14 days. The films exhibited sustained drug-release performances because of the hydrophobicity and nonbiodegradable nature of PU for perivascular drug administration